Publications

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64 Publications visible to you, out of a total of 64
Patient-specific vascularized tumor model: Blocking monocyte recruitment with multispecific antibodies targeting CCR2 and CSF-1R

Abstract

Not specified

Authors: Huu Tuan Nguyen, Ellen L. Kan, Mouhita Humayun, Nadia Gurvich, Giovanni S. Offeddu, Zhengpeng Wan, Mark F. Coughlin, Diana C. Renteria, Andreas Loew, Susan Wilson, Christie Zhang, Vivian Vu, Sharon Wei Ling Lee, Seng-Lai Tan, David Barbie, Jonathan Hsu, Mark Robert Gillrie, Roger D. Kamm

Date Published: 2025

Publication Type: Journal Article

Chromatin conformation, gene transcription, and nucleosome remodeling as an emergent system

Abstract

Not specified

Authors: Luay M. Almassalha, Marcelo Carignano, Emily Pujadas Liwag, Wing Shun Li, Ruyi Gong, Nicolas Acosta, Cody L. Dunton, Paola Carrillo Gonzalez, Lucas M. Carter, Rivaan Kakkaramadam, Martin Kröger, Kyle L. MacQuarrie, Jane Frederick, I Chae Ye, Patrick Su, Tiffany Kuo, Karla I. Medina, Josh A Pritchard, Andrew Skol, Rikkert Nap, Masato Kanemaki, Vinayak Dravid, Igal Szleifer, Vadim Backman

Date Published: 2025

Publication Type: Journal Article

Myofibroblasts reduce angiogenesis and vasculogenesis in a vascularized microphysiological model of lung fibrosis

Abstract

Not specified

Authors: Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm

Date Published: 2025

Publication Type: Journal Article

Markov field network model of multi-modal data predicts effects of immune system perturbations on intravenous BCG vaccination in macaques

Abstract

Not specified

Authors: Shu Wang, Amy J. Myers, Edward B. Irvine, Chuangqi Wang, Pauline Maiello, Mark A. Rodgers, Jaime Tomko, Kara Kracinovsky, H. Jacob Borish, Michael C. Chao, Douaa Mugahid, Patricia A. Darrah, Robert A. Seder, Mario Roederer, Charles A. Scanga, Philana Ling Lin, Galit Alter, Sarah M. Fortune, JoAnne L. Flynn, Douglas A. Lauffenburger

Date Published: 1st Dec 2024

Publication Type: Journal Article

Confined cell migration along extracellular matrix space in vivo

Abstract

Not specified

Authors: Oleksandr Chepizhko, Josep-Maria Armengol-Collado, Stephanie Alexander, Esther Wagena, Bettina Weigelin, Luca Giomi, Peter Friedl, Stefano Zapperi, Caterina A. M. La Porta

Date Published: 1st Dec 2024

Publication Type: Journal Article

Personalized Vascularized Models of Breast Cancer Desmoplasia Reveal Biomechanical Determinants of Drug Delivery to the Tumor.

Abstract (Expand)

Desmoplasia in breast cancer leads to heterogeneity in physical properties of the tissue, resulting in disparities in drug delivery and treatment efficacy among patients, thus contributing to high … disease mortality. Personalized in vitro breast cancer models hold great promise for high-throughput testing of therapeutic strategies to normalize the aberrant microenvironment in a patient-specific manner. Here, tumoroids assembled from breast cancer cell lines (MCF7, SKBR3, and MDA-MB-468) and patient-derived breast tumor cells (TCs) cultured in microphysiological systems including perfusable microvasculature reproduce key aspects of stromal and vascular dysfunction causing impaired drug delivery. Models containing SKBR3 and MDA-MB-468 tumoroids show higher stromal hyaluronic acid (HA) deposition, vascular permeability, interstitial fluid pressure (IFP), and degradation of vascular HA relative to models containing MCF7 tumoroids or models without tumoroids. Interleukin 8 (IL8) secretion is found responsible for vascular dysfunction and loss of vascular HA. Interventions targeting IL8 or stromal HA normalize vascular permeability, perfusion, and IFP, and ultimately enhance drug delivery and TC death in response to perfusion with trastuzumab and cetuximab. Similar responses are observed in patient-derived models. These microphysiological systems can thus be personalized by using patient-derived cells and can be applied to discover new molecular therapies for the normalization of the tumor microenvironment.

Authors: G. S. Offeddu, E. Cambria, S. E. Shelton, K. Haase, Z. Wan, L. Possenti, H. T. Nguyen, M. R. Gillrie, D. Hickman, C. G. Knutson, R. D. Kamm

Date Published: 16th Oct 2024

Publication Type: Journal Article

Colorimetric Detection of Aqueous N-Nitrosodimethylamine via Photonitrosation of a Naphtholsulfonate Indicator.

Abstract (Expand)

N-Nitrosamines are contaminants found throughout the environment, including in drinking water, and many nitrosamines are likely potent carcinogens. Correspondingly, there is a need for rapid and … cost-effective in-field detection methods that can provide timely information about their contamination levels in water. This study details a colorimetric assay for detecting aqueous N-nitrosodimethylamine (NDMA) by photochemical nitrosation of a commercial naphtholsulfonate, to offer an attractive alternative to traditional laboratory-based analysis. The resulting naphthoquinone-oxime coordinates to aqueous iron(II) ions to form a green complex, allowing for direct visual detection. Characterization via Mossbauer and electron paramagnetic resonance (EPR) spectroscopy, alongside single-crystal structure determination, provides comprehensive structure information on the iron indicator complex. Optimization of detection conditions, including UV irradiation and response times, led to an improved colorimetric detection method with a limit of detection of 0.66 ppm for NDMA. The practical applicability and selectivity of this colorimetric detection scheme make it a promising candidate for the development of field-deployable sensors for NDMA in environmental water samples.

Authors: J. C. Beard, C. H. Wang, A. Sridharan, R. G. Croy, J. M. Essigmann, T. M. Swager

Date Published: 27th Sep 2024

Publication Type: Journal Article

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