Publications

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64 Publications visible to you, out of a total of 64
Personalized Vascularized Models of Breast Cancer Desmoplasia Reveal Biomechanical Determinants of Drug Delivery to the Tumor

Abstract

Not specified

Authors: Giovanni S. Offeddu, Elena Cambria, Sarah E. Shelton, Kristina Haase, Zhengpeng Wan, Luca Possenti, Huu Tuan Nguyen, Mark R. Gillrie, Dean Hickman, Charles G. Knutson, Roger D. Kamm

Date Published: 1st Jul 2024

Publication Type: Journal Article

Polyploidy of MDA-MB-231 cells drives increased extravasation with enhanced cell-matrix adhesion

Abstract

Not specified

Authors: Satomi Hirose, Tatsuya Osaki, Roger D. Kamm

Date Published: 1st Jul 2024

Publication Type: Journal Article

Systematic deconstruction of myeloid cell signaling in tuberculosis granulomas reveals IFN-γ, TGF-β, and time are associated with conserved myeloid diversity

Abstract

Not specified

Authors: Joshua M. Peters, Hannah P. Gideon, Travis K. Hughes, Cal Gunnarson, Pauline Maiello, Douaa Mugahid, Sarah K. Nyquist, Joshua D. Bromley, Paul C. Blainey, Beth F. Junecko, Molly L. Nelson, Douglas A. Lauffenburger, Philana Ling Lin, JoAnne L. Flynn, Alex K. Shalek, Sarah M. Fortune, Joshua T. Mattila, Bryan D. Bryson

Date Published: 1st May 2024

Publication Type: Journal Article

Age and sex influence antibody profiles associated with tuberculosis progression.

Abstract

Not specified

Authors: Leela R. L. Davies, Chuangqi Wang, Pia Steigler, Kathryn A. Bowman, Stephanie Fischinger, Mark Hatherill, Michelle Fisher, Stanley Kimbung Mbandi, Miguel Rodo, Tom H. M. Ottenhoff, Hazel M. Dockrell, Jayne S. Sutherland, Harriet Mayanja-Kizza, W. Henry Boom, Gerhard Walzl, Stefan H. E. Kaufmann, Elisa Nemes, Thomas J. Scriba, Douglas Lauffenburger, Galit Alter, Sarah M. Fortune

Date Published: 24th Apr 2024

Publication Type: Journal Article

CD8+ lymphocytes are critical for early control of tuberculosis in macaques

Abstract

Not specified

Authors: Caylin G. Winchell, Sarah K. Nyquist, Michael C. Chao, Pauline Maiello, Amy J. Myers, Forrest Hopkins, Michael Chase, Hannah P. Gideon, Kush V. Patel, Joshua D. Bromley, Andrew W. Simonson, Roisin Floyd-O’Sullivan, Marc Wadsworth, Jacob M. Rosenberg, Rockib Uddin, Travis Hughes, Ryan J. Kelly, Josephine Griffo, Jaime Tomko, Edwin Klein, Bonnie Berger, Charles A. Scanga, Joshua Mattila, Sarah M. Fortune, Alex K. Shalek, Philana Ling Lin, JoAnne L. Flynn

Date Published: 16th Oct 2023

Publication Type: Journal Article

Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk.

Abstract (Expand)

BACKGROUND: The human endometrium undergoes recurring cycles of growth, differentiation, and breakdown in response to sex hormones. Dysregulation of epithelial-stromal communication during hormone-mediated … signaling may be linked to myriad gynecological disorders for which treatments remain inadequate. Here, we describe a completely defined, synthetic extracellular matrix that enables co-culture of human endometrial epithelial and stromal cells in a manner that captures healthy and disease states across a simulated menstrual cycle. METHODS: We parsed cycle-dependent endometrial integrin expression and matrix composition to define candidate cell-matrix interaction cues for inclusion in a polyethylene glycol (PEG)-based hydrogel crosslinked with matrix metalloproteinase-labile peptides. We semi-empirically screened a parameter space of biophysical and molecular features representative of the endometrium to define compositions suitable for hormone-driven expansion and differentiation of epithelial organoids, stromal cells, and co-cultures of the two cell types. FINDINGS: Each cell type exhibited characteristic morphological and molecular responses to hormone changes when co-encapsulated in hydrogels tuned to a stiffness regime similar to the native tissue and functionalized with a collagen-derived adhesion peptide (GFOGER) and a fibronectin-derived peptide (PHSRN-K-RGD). Analysis of cell-cell crosstalk during interleukin 1B (IL1B)-induced inflammation revealed dysregulation of epithelial proliferation mediated by stromal cells. CONCLUSIONS: Altogether, we demonstrate the development of a fully synthetic matrix to sustain the dynamic changes of the endometrial microenvironment and support its applications to understand menstrual health and endometriotic diseases. FUNDING: This work was supported by The John and Karine Begg Foundation, the Manton Foundation, and NIH U01 (EB029132).

Authors: J. S. Gnecco, A. Brown, K. Buttrey, C. Ives, B. A. Goods, L. Baugh, V. Hernandez-Gordillo, M. Loring, K. B. Isaacson, L. G. Griffith

Date Published: 11th Aug 2023

Publication Type: Journal Article

Humoral correlates of protection against <i>Mycobacterium tuberculosis</i> following intravenous Bacille Calmette-Guérin vaccination in rhesus macaques.

Abstract

Not specified

Authors: Edward B. Irvine, Patricia A. Darrah, Shu Wang, Chuangqi Wang, Ryan P. McNamara, Mario Roederer, Robert A. Seder, Douglas A. Lauffenburger, JoAnne L. Flynn, Sarah M. Fortune, Galit Alter

Date Published: 2nd Aug 2023

Publication Type: Journal Article

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