Studies
What is a Study?
Patricia S. Grace, Joshua M. Peters, Jaimie Sixsmith, Richard Lu, Corinne Luedeman, Brooke A. Fenderson, Andrew Vickers, Matthew D. Slein, Edward B. Irvine, Tanya McKitrick, Mo-Hui Wei, Richard D. Cummings, Aaron Wallace, Lisa A. Cavacini, Alok Choudhary, Megan K. Proulx, Christopher Sundling, Gunilla Källenius, Rajko Reljic, Joel D. Ernst, Arturo Casadevall, Camille Locht, Abraham Pinter, Christopher M. Sasseti, Bryan D. Bryson, Sarah M. Fortune, Galit Alter
...
Submitter: Demo Demo
Investigation: Impact
Assays: ADCD Analysis - Data Linked, ADFP Analysis - Data Linked, Antibody Dependent Complement Deposition - Data Linked, Antibody Dependent Functional Profiling - Data Linked, Bacterial Survivability Restriction Assay - Data Linked, Cell Extraction - Metadata, Cell Sorting – Data Linked, ELISA Assay - Data Linked, FC-Receptor Binding Assay - Data Linked, Flow Cytometry - Data Linked, Flow Cytometry Analysis - Data Linked, Mouse Challenge – Metadata, Short Read Sequencing - Data Linked, Single Cell Clustering - Data Linked, Single Cell Expression Analysis - Data Linked, Tissue Collection – Metadata, Western Blot - Data Linked
Auto-created study: Intravenous BCG vaccination induces recruitment of Granzyme B+ Natural Killer cells to the lungs which is associated with protection against Mycobacterium tuberculosis in rhesus macaques
Submitter: Demo Demo
Investigation: Impact
Assays: Flow Cytometry - Data Linked, Flow Cytometry Analysis - Data Linked, Library Creation - Metadata, Mass Cytometry - Data Linked, Mass Cytometry Analysis - Data Linked, Patient Visit - Metadata, Short Read Sequencing - Data Linked, Tissue Collection - Metadata
Joshua M. Peters, Hannah P. Gideon, Travis K. Hughes, Cal Gunnarson, Pauline Maiello, Douaa Mugahid, Sarah K. Nyquist, Joshua D. Bromley, Paul C. Blainey, Beth F. Junecko, Molly L. Nelson, Douglas A. Lauffenburger, Philana Ling Lin, JoAnne L. Flynn, Alex K. Shalek, Sarah M. Fortune, Joshua T. Mattila, Bryan D. Bryson
DOI: https://www.biorxiv.org/content/10.1101/2024.05.24.595747v1.full
Additional Datasets:
- More Metadata associated with these NHPs exists ...
Krista M. Pullen, Ryan Finethy, Seung-Hyun B. Ko, Charlotte J. Reames, Christopher M. Sassetti, Douglas A. Lauffenburger
DOI:
Abstract:Numerous studies have identified similarities in blood transcriptomic signatures of mouse tuberculosis (TB) models and human disease phenotypes, such as type 1 interferon (IFN) production and innate immune cell activation, yet the pathophysiology observed in murine infection does not recapitulate some of the hallmarks of human ...
Submitter: Demo Demo
Investigation: Impact
Assays: Bacterial Survivability Restriction Assay: Validation Data - Data Attached, Cell Extraction: Validation Data - Metadata, Gene Expression Analysis: Training Data - Data Linked, Gene Expression Analysis: Validation Data - Data Linked, Library Prep: Training Data - Metadata, Library Prep: Validation Data - Metadata, PCR: Validation Data - Data Attached, RNA Extraction: Validation Data - Metadata, Short Read Sequencing: Training Data - Data Linked, Short Read Sequencing: Validation Data - Data Linked, Tissue Collection: Training Data - Metadata, TransCompR Cross Species Modeling - Data Linked
_Andrew W. Simonson, Joseph J. Zeppa, Allison N. Bucsan, Michael C. Chao, Supriya Pokkali, Forrest Hopkins, Michael R. Chase, Andrew J. Vickers, Matthew S. Sutton, Caylin G. Winchell, Amy J. Myers, Cassaundra L. Ameel, Ryan Kelly, Ben Krouse, Luke E. Hood, Jiaxiang Li, Chelsea C. Lehman, Megha Kamath, Jaime Tomko, Mark A. Rodgers, Rachel Donlan, Harris Chishti, H. Jacob Borish, Edwin Klein, Charles A. Scanga, Sarah Fortune, Philana Ling Lin, Pauline Maiello, Mario Roederer, Patricia A. Darrah, ...
Submitter: Demo Demo
Investigation: Impact
Assays: Bacterial Extraction - Metadata, Digitally Barcoded Mtb Matrix Analysis - Data Attached, Flow Cytometry - Data Linked, Library Prep - Metadata, PET-CT Scan - Data Linked, Patient Visit - Metadata, Short Read Sequencing - Data Linked, Tissue Collection - Metadata
Joshua M. Peters, Edward B. Irvine, Jacob M. Rosenberg, Marc H. Wadsworth II, Travis K. Hughes, Matthew Sutton, Sarah K. Nyquist, Joshua D. Bromley, Rajib Mondal, Mario Roederer, Robert A. Seder, Patricia A. Darrah, Galit Alter, JoAnne L. Flynn, Alex K. Shalek, Sarah M. Fortune, Bryan D. Bryson
DOI: https://www.science.org/doi/10.1126/sciadv.adq8229
Intradermal Bacillus Calmette-Guérin (BCG) is the most widely administered vaccine, but it does not sufficiently ...
Submitter: Demo Demo
Investigation: Impact
Assays: Library Creation - Metadata, Patient Visit - Metadata, Short Read Sequencing - Data Linked, Single Cell Expression Analysis - Data Linked, Tissue Collection - Metadata
Megan K. Proulx, Christine D. Wiggins, Charlotte J. Reames, Claire Wu, Michael C. Kiritsy, Patricia Grace, Clare M. Smith, Cecelia S. Lindestam Arlehamn, Galit Alter, Douglas A. Lauffenburger, Christopher M. Sassetti
Training Data for the Model: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE267774
Abstract: While control of Mycobacterium tuberculosis (Mtb) infection is generally understood to require a Th1-immune response and IFN secretion, infection ...
Submitter: Demo Demo
Investigation: Impact
Assays: CITESEQ Analysis - Data Linked, Cell Isolation - Metadata, Flow Cytometry - Data Linked, Flow Cytometry Analysis - Data Linked, Histology - Data Linked, Library Prep - Metadata, Model Validation - Data Linked, Pathogen Challenge and Antibody Depletion - Metadata, Short Read Sequencing - Data Linked, Tissue Collection - Metadata
