Impact

Testing Space

This study investigates how Fc-engineered antibodies affect Mycobacterium tuberculosis (Mtb) growth through antibody-dependent enhancement (ADE). We engineered 16 Fc variants with two distinct Fab regions (710 and 712), both targeting antigen85B (Ag85B), creating 32 total antibody variants. These variants were comprehensively profiled across five antibody effector functions: antibody-dependent neutrophil phagocytosis (ADNP), antibody-dependent monocyte phagocytosis (ADMP), antibody-dependent ...

Abiola F. Ogunsola, Rocky Lai, Kelly Cavallo, Gillian L. Beamer, and Samuel M. Behar

DOI:

Abstract: Vaccine development for tuberculosis is a global priority. Our studies using Collaborative Cross (CC) mice show that genetic diversity influences the efficacy of BCG, the most widely used TB vaccine. BCG vaccination of CC042 mice reduces their lung bacillary burden and increases their survival following low-dose aerosol Mycobacterium tuberculosis infection ...